MyOme waxay soo bandhigtay xog laga helay boodhadh ka soo baxay shirweynaha Bulshada Maraykanka ee Hiddaha Aadamiga (ASHG) kaas oo diiradda saaraya dhibcaha khatarta ah ee isku dhafan ee polygenic (caIRS), kaas oo isku daraya hidda-socodka iyo arrimaha khatarta caafimaad ee dhaqameed si loo hagaajiyo aqoonsiga shakhsiyaadka khatarta sare leh ee cudurka halbowlaha wadnaha (CAD) oo ka kooban dadyow kala duwan.
Natiijooyinku waxay muujiyeen in caIRS si sax ah loo aqoonsaday shakhsiyaadka khatarta sare leh ugu jira inay qaadaan cudurka halbowlaha wadnaha, gaar ahaan xuduudaha xuduudaha ama qaybaha khatarta kiliinikada ee dhexdhexaadka ah iyo shakhsiyaadka Koonfurta Aasiya.
Dhaqan ahaan, inta badan aaladaha qiimeynta halista CAD iyo imtixaanada waxaa lagu ansixiyey dad aad u yar, sida uu qabo Akash Kumar, MD, PhD, madaxa caafimaadka iyo sarkaalka sayniska ee MyOme.Qalabka inta badan la isticmaalo, Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), waxay ku tiirsan tahay cabbirada caadiga ah sida heerarka kolestaroolka iyo heerka sonkorowga si loo saadaaliyo khatarta CAD 10-sano ah iyo hagitaan go'aamo ku saabsan bilawga daaweynta statin, ayuu yiri Kumar. .
Wuxuu isku daraa malaayiin nooc oo hidde-sideyaal ah
Dhibcaha halista polygenic (PRS), kuwaas oo isku geynaya malaayiin kala duwanaansho hidde-side ah oo cabbirkoodu yar yahay hal dhibic, ayaa bixiya suurtagalnimada in lagu wanaajiyo saxnaanta aaladaha qiimeynta khatarta caafimaad, "ayuu sii raaciyay Kumar.MyOme waxa ay samaysay oo ansixisay dhibco khatar ah oo isku dhafan taas oo isku darka PRS-ta abtirsiinyada iyo caIRS.
Natiijooyinka muhiimka ah ee ka soo baxay bandhigga waxay muujiyeen in caIRS ay si weyn u wanaajisay takoorka marka la barbar dhigo PCE-ga dhammaan kooxaha ansaxinta iyo awoowyada la tijaabiyay.CaIRS waxay kaloo aqoonsatay ilaa 27 kiis oo dheeraad ah oo CAD ah 1,000kii qof ee ka tirsan kooxda PCE ee xadka/dhexe.Intaa waxaa dheer, shakhsiyaadka Koonfurta Aasiya waxay muujiyeen kororka ugu weyn ee takoorka.
"Dhibcaha khatarta isku dhafan ee MyOme waxay kor u qaadi kartaa ka-hortagga cudurrada iyo maaraynta daryeelka aasaasiga ah iyada oo la aqoonsanayo shakhsiyaadka khatarta sare leh ee horumarinta CAD, kuwaas oo laga yaabo in si kale loo seegay," ayuu yidhi Kumar."Waxa xusid mudan, caIRS waxay si aad ah waxtar ugu lahayd aqoonsiga shakhsiyaadka Koonfurta Aasiya ee khatarta ugu jira CAD, taas oo muhiim u ah heerka dhimashada CAD ee ku dhawaad labanlaab marka la barbardhigo dadka reer Yurub."
Soo bandhigida boodhka Myome waxa cinwaan looga dhigay "Isku dhafka Dhibcaha Khatarta Badan ee Jirka iyo Sababaha Kiliinikada Waxay Wanaajisaa Saadaasha Khatarta 10-sano ee Cudurka Halbowlaha Wadnaha."
Waqtiga boostada: Nov-10-2023